Has anyone had any success with this yet? [The WineHQ AppDB][link] has some promising info but none that I can make work on my Macintosh with the MacPorts version of Wine-devel.
*UPDATE:* I eventually had success with [this Wineskin wrapper][wine].
[link]: http://appdb.winehq.org/objectManager.php?sClass=application&iId=13667 “Skyrim on WineHQ”
[wine]: http://portingteam.com/2011/11/skyrim-mac-port/ “Skyrim Mac Wrapper”